Fig. 1 · Structure
Documents & Downloads
DC44SMe
Phosphate Prodrug
DC44SMe is a phosphate prodrug of the cytotoxic DNA alkylator DC44, designed for use in the synthesis of antibody-drug conjugates (ADCs). It demonstrates potent cytotoxicity, with IC50 values of 2.0 nM, 2.8 nM, and 1.9 nM against Ramos, Namalwa, and HL60/s cancer cell lines, respectively. This compound is suitable for targeted cancer therapies, enabling the delivery of cytotoxic agents specifically to tumor cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1354787-76-0 |
| Applications | Phosphate Prodrug |
| Formula | C38H37ClN5O7PS2 |
| Molecular Weight | 806.29 |
| SMILES | O=C(C(N1)=CC2=C1C=CC(NC(CCC(SSC)(C)C)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(OP(O)(O)=O)C7=CC=CC=C67)=O)=C4)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.