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DCG-IV

Catalog No.: A61759
Group II mGluRs Agonist
DCG-IV is a potent agonist of group II metabotropic glutamate receptors (mGluRs), displaying EC50 values of 0.35 μM for mGlu2R and 0.09 μM for mGlu3R. Additionally, it acts as a competitive antagonist at group I and group III mGluRs, with respective IC50 values of 389 μM and 22.5-630 μM. DCG-IV has demonstrated anticonvulsive and neuroprotective properties, making it valuable for research in neurobiology and pharmacology.
DCG-IV 147782-19-2 Group II mGluRs Agonist
Grouped product items
Size Price Stock Qty
1mg
$585.00
In stock
10mg
$1,930.00
In stock
50mg
$7,620.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDCG-IV is a potent agonist of group II metabotropic glutamate receptors (mGluRs), displaying EC50 values of 0.35 μM for mGlu2R and 0.09 μM for mGlu3R. Additionally, it acts as a competitive antagonist at group I and group III mGluRs, with respective IC50 values of 389 μM and 22.5-630 μM. DCG-IV has demonstrated anticonvulsive and neuroprotective properties, making it valuable for research in neurobiology and pharmacology.
Product Information
Catalog NumA61759
FormulaC7H9NO6
Molecular Weight203.15
CAS Number147782-19-2
SMILESO=C([C@H]1[C@H](C(O)=O)C1[C@H](N)C(O)=O)O
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GPCR/G Protein > Metabotropic glutamate receptors (mGluR)