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DDD489

Cryptosporidium lysyl-tRNA Synthetase Inhibitor

DDD489 is a potent inhibitor of Cryptosporidium lysyl-tRNA synthetase (CpKRS), exhibiting an IC50 value of 0.85 µM. This compound demonstrates significant anti-cryptosporidial activity both in vitro and in vivo, making it a valuable tool for research focused on Cryptosporidium infections and related therapeutic development. Its selectivity towards CpKRS enhances its potential for studying the biochemical pathways underlying Cryptosporidium's lifecycle and pathogenesis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3003871-42-6
Applications	Cryptosporidium lysyl-tRNA Synthetase Inhibitor
Formula	C₁₅H₁₆F₆N₄O
Molecular Weight	382.30
SMILES	O=C1N(C[C@H]2C[C@@H](C(F)(F)F)CCC2)CC3=NC(N)=NC(C(F)(F)F)=C31

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.