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DDN

Insulin Receptor Activators

DDN is a selective activator of the insulin receptor, functioning as an insulin sensitizer and glucose-lowering insulin mimetic with oral bioavailability. It interacts with the receptor kinase domain, leading to phosphorylation of Akt and ERK, while enhancing insulin-mediated glucose uptake. In studies, DDN has demonstrated a significant reduction in blood glucose levels in both wild-type and diabetic ob/ob and db/db mouse models, highlighting its potential for diabetes research applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Activator
CAS Number	118006-14-7
Applications	Insulin Receptor Activators
Formula	C₁₄H₈Cl₂O₆
Molecular Weight	343.12
SMILES	O=C1C(Cl)=C(Cl)C(C2=C1C(OC(C)=O)=CC=C2OC(C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.