Fig. 1 · Structure
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DDO-6079
CDC37 Inhibitor
DDO-6079 is a potent inhibitor of CDC37, a key chaperone protein involved in the stabilization and activation of various client proteins. By binding to an allosteric site on CDC37, DDO-6079 disrupts the HSP90-CDC37 and CDC37-CDK4/6 chaperone complexes, leading to reduced thermostability of CDK6. This compound is valuable for research applications aimed at understanding the role of CDC37 in cellular signaling and cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2648334-53-4 |
| Applications | CDC37 Inhibitor |
| Formula | C18H13ClN2O3 |
| Molecular Weight | 340.76 |
| SMILES | O=C(C1=CC(Cl)=CC=C1O)NC2=CC(OC3=CC=CC=C3)=NC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.