DDO3711 is a specific inhibitor of apoptosis signal-regulated kinase 1 (ASK1), exhibiting an IC50 of 164.1 nM while displaying minimal inhibition of ASK2 (IC50 > 20 μM). This compound functions by dephosphorylating phosphorylated ASK1 at threonine 838 through recruitment of the phosphatase PP5. DDO3711 demonstrates significant ASK1-dependent antiproliferative effects and shows promise in studies related to cancer by targeting abnormally phosphorylated oncoproteins.
DDO3711 is a specific inhibitor of apoptosis signal-regulated kinase 1 (ASK1), exhibiting an IC50 of 164.1 nM while displaying minimal inhibition of ASK2 (IC50 > 20 μM). This compound functions by dephosphorylating phosphorylated ASK1 at threonine 838 through recruitment of the phosphatase PP5. DDO3711 demonstrates significant ASK1-dependent antiproliferative effects and shows promise in studies related to cancer by targeting abnormally phosphorylated oncoproteins.
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