Fig. 1 · Structure
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DDR Inhibitor
Discoidin Domain Receptor Inhibitor
DDR Inhibitor is a highly selective inhibitor of the discoidin domain receptors (DDRs), specifically demonstrating an IC50 of 3.3 nM for DDR2. Additionally, it exhibits a significant inhibitory effect on DDR1, with 53% inhibition at a concentration of 1.5 nM. This compound is valuable for investigating the role of DDRs in cellular processes and may have applications in cancer research and fibrosis studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1644069-80-6 |
| Applications | Discoidin Domain Receptor Inhibitor |
| Formula | C23H20FN5O2 |
| Molecular Weight | 417.44 |
| SMILES | O=C(C1=CN=C2C=CC=CN21)NC3=CC(CNC(NC4=CC=CC(F)=C4)=O)=CC=C3C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.