DDR1-IN-12 is a selective inhibitor of discoidin domain receptor 1 (DDR1), exhibiting an IC50 of 0.126 μM. This compound effectively blocks receptor tyrosine kinase autophosphorylation, thereby inhibiting downstream signaling pathways, including the suppression of TGF-β1-induced fibroblast activation. DDR1-IN-12 demonstrates significant potential in research applications related to tumor cell migration and the progression of pulmonary fibrosis, making it particularly relevant for studies involving lung cancer, including lung adenocarcinoma.
DDR1-IN-12 is a selective inhibitor of discoidin domain receptor 1 (DDR1), exhibiting an IC50 of 0.126 μM. This compound effectively blocks receptor tyrosine kinase autophosphorylation, thereby inhibiting downstream signaling pathways, including the suppression of TGF-β1-induced fibroblast activation. DDR1-IN-12 demonstrates significant potential in research applications related to tumor cell migration and the progression of pulmonary fibrosis, making it particularly relevant for studies involving lung cancer, including lung adenocarcinoma.
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