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DDR1-IN-12

DDR1 Inhibitor

DDR1-IN-12 is a selective inhibitor of discoidin domain receptor 1 (DDR1), exhibiting an IC50 of 0.126 μM. This compound effectively blocks receptor tyrosine kinase autophosphorylation, thereby inhibiting downstream signaling pathways, including the suppression of TGF-β1-induced fibroblast activation. DDR1-IN-12 demonstrates significant potential in research applications related to tumor cell migration and the progression of pulmonary fibrosis, making it particularly relevant for studies involving lung cancer, including lung adenocarcinoma.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3038810-93-1
Applications	DDR1 Inhibitor
Formula	C₂₄H₂₅F₄N₅O₂
Molecular Weight	491.48
SMILES	O=C(NCC1=CN(CC(N2CCN(CC2)C)=O)C3=C1C=C(F)C=C3)NC4=CC=C(C(F)(F)F)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.