DDR1-IN-4 is a selective inhibitor of Discoidin Domain Receptor 1 (DDR1), effectively blocking its autophosphorylation with an IC50 of 29 nM. This compound exhibits significantly lower activity against DDR2, with an IC50 of 1.9 μM. DDR1-IN-4 is utilized in research applications focusing on cell signaling, extracellular matrix interactions, and cancer biology, providing valuable insights into the role of DDR1 in various pathological conditions.
DDR1-IN-4 is a selective inhibitor of Discoidin Domain Receptor 1 (DDR1), effectively blocking its autophosphorylation with an IC50 of 29 nM. This compound exhibits significantly lower activity against DDR2, with an IC50 of 1.9 μM. DDR1-IN-4 is utilized in research applications focusing on cell signaling, extracellular matrix interactions, and cancer biology, providing valuable insights into the role of DDR1 in various pathological conditions.
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