Fig. 1 · Structure
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DDR1-IN-9
Discoidin Domain Receptor Inhibitor
DDR1-IN-9 is a selective inhibitor of the Discoidin Domain Receptor 1 (DDR1), known for its significant suppression of kinase activity, with a Kd value of 4.7 nM and an IC50 value of 9.4 nM. Demonstrating reduced activity against a broad panel of 400 nonmutated kinases, DDR1-IN-9 exhibits a favorable specificity profile. This compound also possesses beneficial pharmacokinetic properties and has displayed potential therapeutic effects in experimental models of pulmonary fibrosis, making it a valuable tool for researching fibrotic diseases and DDR1-related signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1934246-20-4 |
| Applications | Discoidin Domain Receptor Inhibitor |
| Formula | C26H23F3N6O |
| Molecular Weight | 492.50 |
| SMILES | C[C@H]1C2=CC=C(C(NC3=CC(N4C=NC(C)=C4)=CC(C(F)(F)F)=C3)=O)C=C2CN(C5=CN=CN=C5)C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.