DDR1-IN-9 is a selective inhibitor of the Discoidin Domain Receptor 1 (DDR1), known for its significant suppression of kinase activity, with a Kd value of 4.7 nM and an IC50 value of 9.4 nM. Demonstrating reduced activity against a broad panel of 400 nonmutated kinases, DDR1-IN-9 exhibits a favorable specificity profile. This compound also possesses beneficial pharmacokinetic properties and has displayed potential therapeutic effects in experimental models of pulmonary fibrosis, making it a valuable tool for researching fibrotic diseases and DDR1-related signaling pathways.
DDR1-IN-9 is a selective inhibitor of the Discoidin Domain Receptor 1 (DDR1), known for its significant suppression of kinase activity, with a Kd value of 4.7 nM and an IC50 value of 9.4 nM. Demonstrating reduced activity against a broad panel of 400 nonmutated kinases, DDR1-IN-9 exhibits a favorable specificity profile. This compound also possesses beneficial pharmacokinetic properties and has displayed potential therapeutic effects in experimental models of pulmonary fibrosis, making it a valuable tool for researching fibrotic diseases and DDR1-related signaling pathways.
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