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- Jamie L. Dombach, .et al. A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids, PLoS Pathog, 2020, Dec; 16(12): e1009119 PMID: 33290418
Biological Activity
Deferasirox is a rationally-designed oral iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor.
| In vitro (25°C) | DMSO | 64 mg/mL (171.42 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL | ||
| In vivo | 5% DMSO+40% PEG 300+5%Tween 80 +50 % H2O | 3.5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.78 mL | 133.92 mL | 267.84 mL |
| 0.5 mM | 5.36 mL | 26.78 mL | 53.57 mL |
| 1 mM | 2.68 mL | 13.39 mL | 26.78 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.36 mL |
*The above data is based on the productmolecular weight 373.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10293 |
|---|---|
| CAS No. | 201530-41-8 |
| Formula | C21H15N3O4 |
| M. Wt | 373.36 |
| Purity | >98% |
| Synonyms | ICL-670, ICL-670A, CGP-72670 |
| SMILES | C1=C/C(=C\2/N/C(=C\3/C=CC=CC3=O)/N(N2)C4=CC=C(C=C4)C(=O)O)/C(=O)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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