Deferasirox

Catalog No.: A10293

Iron chelator

Deferasirox

Deferasirox Chemical Structure

CAS NO. 201530-41-8

Deferasirox is a rationally-designed oral iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor.

Availability: In stock

Package Price Qty
5 mg
$45.00
10 mg
$65.00
25 mg
$80.00
50 mg
$125.00
10mM * 1mL in DMSO
$96.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Deferasirox is a rationally-designed oral iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor.
In vitro (25°C) DMSO 64 mg/mL (171.42 mM)
Water Insoluble
Ethanol 2 mg/mL
In vivo 5% DMSO+40% PEG 300+5%Tween 80 +50 % H2O 3.5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.78 mL 133.92 mL 267.84 mL
0.5 mM 5.36 mL 26.78 mL 53.57 mL
1 mM 2.68 mL 13.39 mL 26.78 mL
5 mM 0.54 mL 2.68 mL 5.36 mL

*The above data is based on the productmolecular weight 373.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10293
CAS No. 201530-41-8
Formula C21H15N3O4
M. Wt 373.36
Solubility DMSO
Purity >98%
Synonyms ICL-670, ICL-670A, CGP-72670
SMILES C1=C/C(=C\2/N/C(=C\3/C=CC=CC3=O)/N(N2)C4=CC=C(C=C4)C(=O)O)/C(=O)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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