Fig. 1 · Structure
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Dehydronitrosonisoldipine
SARM1 Inhibitor
Dehydronitrosonisoldipine is an irreversible inhibitor of sterile alpha and TIR motif-containing 1 (SARM1), acting primarily by blocking SARM1 activation without affecting its enzymatic functions. This compound covalently modifies critical cysteine residues, effectively inhibiting SARM1 and mitigating axon degeneration, as well as reducing vincristine-induced cADPR production in neurons. Dehydronitrosonisoldipine is a valuable tool for investigating the molecular mechanisms of neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 87375-91-5 |
| Applications | SARM1 Inhibitor |
| Formula | C20H22N2O5 |
| Molecular Weight | 370.40 |
| SMILES | O=C(C1=C(C2=CC=CC=C2N=O)C(C(OCC(C)C)=O)=C(C)N=C1C)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.