Fig. 1 · Structure
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Dendrogenin A
LXR Ligand
Dendrogenin A (DDA) is a selective ligand for the liver X receptor (LXR) that promotes the expression of the sodium/iodine symporter, leading to enhanced iodine uptake. This compound has been shown to induce cell differentiation in MCF-7 breast cancer cells and reactivate the function of lactating cells. Dendrogenin A also upregulates the expression of the thyroid-stimulating hormone receptor, thyroid peroxidase, and thyroglobulin, influencing the generation of thyroid hormones. Additionally, DDA exhibits cytotoxic effects on cancer cell lines B-CPAP and 8505c, with IC50 values of 4.1 and 6.2 µM, respectively, and it effectively arrests the cell cycle at the G0/G1 phase.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1191043-85-2 |
| Applications | LXR Ligand |
| Formula | C32H55N3O2 |
| Molecular Weight | 513.80 |
| Synonyms | DDA |
| SMILES | C[C@@]12[C@]3([H])[C@](C[C@H]([C@]1(C[C@H](CC2)O)O)NCCC4=CN=CN4)([H])[C@@]5([H])[C@](CC3)([C@@](CC5)([H])[C@H](C)CCCC(C)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.