Fig. 1 · Structure
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Depiperazine-DM3189
ALK2/3 Inhibitor
Depiperazine-DM3189 is an inhibitor of the ALK2 and ALK3 receptors, which are associated with bone morphogenetic protein (BMP) signaling pathways. It exerts significant biological activity by selectively inhibiting the transcriptional activity of these BMP type I receptors, with IC50 values of 5 nM for ALK2 and 30 nM for ALK3. This compound serves as a valuable tool for investigating BMP signaling in various research applications, including the study of diseases such as fibrodysplasia ossificans progressiva.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1062368-55-1 |
| Applications | ALK2/3 Inhibitor |
| Formula | C21H14N4 |
| Molecular Weight | 322.36 |
| Synonyms | Depiperazine-LDN-193189 |
| SMILES | C1(C2=C3N=CC(C4=CC=CC=C4)=CN3N=C2)=CC=NC5=CC=CC=C15 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.