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Desamino lenalidomide-4-Br-5-F

Ligand for E3 Ligase

Desamino lenalidomide-4-Br-5-F is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to create PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its ability to modulate protein degradation makes it valuable in various research applications, including targeted protein elimination and the study of cellular mechanisms involving ubiquitin-proteasome pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2619512-24-0
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀BrFN₂O₃
Molecular Weight	341.14
SMILES	O=C1NC(=O)C(N2C(=O)C3=CC=C(F)C(Br)=C3C2)CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.