Desamino lenalidomide-5-CO is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to facilitate the formation of proteolysis-targeting chimeras (PROTACs). Its application in protein degradation studies makes it a valuable tool for exploring therapeutic strategies in various diseases, including cancer.
Desamino lenalidomide-5-CO is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to facilitate the formation of proteolysis-targeting chimeras (PROTACs). Its application in protein degradation studies makes it a valuable tool for exploring therapeutic strategies in various diseases, including cancer.
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