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Desamino lenalidomide-5-CO

Ligand for E3 Ligase

Desamino lenalidomide-5-CO is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to facilitate the formation of proteolysis-targeting chimeras (PROTACs). Its application in protein degradation studies makes it a valuable tool for exploring therapeutic strategies in various diseases, including cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2866307-09-5
Applications	Ligand for E3 Ligase
Formula	C₁₄H₁₂N₂O₄
Molecular Weight	272.26
SMILES	O=CC1=CC=C2C(=C1)C(=O)N(C2)C3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.