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Desfluoro-BMS-694153

CGRP Receptor Antagonist

Desfluoro-BMS-694153 is a potent antagonist of the calcitonin gene-related peptide (CGRP) receptor, with a Ki value of 0.01 nM. This compound exhibits minimal risk of CYP3A4 inhibition, demonstrated by IC50 values of 36 μM for CYP3A4-BFC and 6 μM for CYP3A4-BZR. Desfluoro-BMS-694153 is primarily utilized in research focused on migraine pathophysiology and the exploration of therapeutic interventions targeting CGRP pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	773886-89-8
Applications	CGRP Receptor Antagonist
Formula	C₃₅H₄₆N₈O₃
Molecular Weight	626.79
SMILES	O=C1N(C2CCN(CC2)C(N[C@@H](C(N3CCC(N4CCCCC4)CC3)=O)CC5=CC(C)=C(NN=C6)C6=C5)=O)CC7=CC=CC=C7N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.