Fig. 1 · Structure
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Desloratadine
H1-Receptor Antagonist
Desloratadine is a selective H1 receptor antagonist characterized by its high affinity (Ki = 0.9 nM) for the receptor. It exhibits notable anti-inflammatory and anti-allergic properties by inhibiting the release of histamine and LTC4 from human basophils and modulating IL-4 and IL-13 production. This compound serves as an effective therapeutic agent for alleviating symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria, especially in patients with concurrent asthma, making it valuable for research in allergy and immunology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 100643-71-8 |
| Applications | H1-Receptor Antagonist |
| Formula | C19H19ClN2 |
| Molecular Weight | 310.83 |
| Synonyms | Sch34117 |
| SMILES | ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.