Fig. 1 · Structure
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Desmethyl Erlotinib
Erlotinib Active Metabolite
Desmethyl Erlotinib is an active metabolite of Erlotinib, primarily targeting the epidermal growth factor receptor (EGFR) as a potent tyrosine kinase inhibitor. This compound serves as a valuable click chemistry reagent, containing an alkyne functional group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC). Its applications include enhancing bioconjugation techniques and facilitating the study of EGFR signaling pathways in various biological research contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 183321-86-0 |
| Applications | Erlotinib Active Metabolite |
| Formula | C21H21N3O4 |
| Molecular Weight | 379.41 |
| Synonyms | OSI-420 free base; CP-373420 |
| SMILES | OCCOC1=CC2=C(N=CN=C2NC3=CC=CC(C#C)=C3)C=C1OCCOC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.