Fig. 1 · Structure
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Desmethylene tadalafil
Tadalafil Metabolite
Desmethylene tadalafil is a metabolite of Tadalafil that primarily functions as a selective inhibitor of phosphodiesterase type 5 (PDE5). This compound is significant in studies investigating the pharmacokinetics and metabolic pathways of Tadalafil, as well as its potential implications in conditions associated with erectile dysfunction and pulmonary hypertension. Its role in enzymatic metabolism, primarily mediated by CYP3A4, makes it relevant for research focused on drug-drug interactions and personalized medicine.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 171489-03-5 |
| Applications | Tadalafil Metabolite |
| Formula | C21H19N3O4 |
| Molecular Weight | 377.39 |
| SMILES | O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(O)C(O)=C3)N14)NC5=C2C=CC=C5)N(C)CC4=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.