Fig. 1 · Structure
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DETQ
Dopamine D1 Receptor Potentiator
DETQ is an allosteric potentiator of the dopamine D1 receptor, enhancing receptor activity through a unique binding site. In HEK293 cells expressing the human D1 receptor, DETQ significantly increases cyclic AMP levels with an EC50 of 5.8 nM and a binding affinity (Kb) of 26 nM. The compound exhibits approximately 30-fold reduced potency at rodent D1 receptors and shows no activity against the human D5 receptor. This specificity makes DETQ a valuable tool for research involving dopamine signaling pathways and their implications in neurobiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1638667-81-8 |
| Applications | Dopamine D1 Receptor Potentiator |
| Formula | C22H25Cl2NO3 |
| Molecular Weight | 422.34 |
| SMILES | C[C@@H]1N(C(CC2=C(Cl)C=CC=C2Cl)=O)[C@@H](CO)CC3=C1C=CC=C3C(C)(O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.