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Other Forms

Form	MW
Dexmecamylamine This page	167.29
S-(+)-Mecamylamine hydrochloride	203.75

Dexmecamylamine

nAChR Antagonist

Dexmecamylamine is a selective antagonist of the nicotinic acetylcholine receptors (nAChR), specifically targeting the α3β4, α4β2, α7, and α1β1γδ subtypes with IC50 values in the micromolar range. This compound demonstrates notable anxiolytic and antidepressant-like effects, making it a valuable tool in neurological research and the study of mood disorders. Its ability to modulate nAChR activity positions it as a potential lead for therapeutic development in psychiatric conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	107538-05-6
Applications	nAChR Antagonist
Formula	C₁₁H₂₁N
Molecular Weight	167.29
Synonyms	(+)-Mecamylamine; TC-5214
SMILES	CN[C@]1([C@@]2([H])C[C@@](CC2)([H])C1(C)C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.