Fig. 1 · Structure
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Dexpramipexole
Mitochondrial Protective Agent
Dexpramipexole, a mitochondrial protective agent, effectively permeates the blood-brain barrier. Its mechanisms include the upregulation of Parkin, PINK1, GPX4, and FSP1, as well as binding to mitochondrial F1/Fo-ATP synthase. Dexpramipexole has demonstrated notable biological activities, such as inducing mitophagy, inhibiting ferroptosis, and alleviating neuroinflammation. This compound is applicable in research fields including eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, and analgesia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 104632-28-2 |
| Applications | Mitochondrial Protective Agent |
| Formula | C10H17N3S |
| Molecular Weight | 211.33 |
| Synonyms | (R)-Pramipexole; R-(+)-Pramipexole; KNS-760704 |
| SMILES | NC1=NC(CC[C@@H](NCCC)C2)=C2S1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.