Fig. 1 · Structure
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dFKBP-1
PROTAC FKBP12 Degrader
dFKBP-1 is a potent PROTAC-based degrader targeting FKBP12. It is composed of the FKBP12-binding ligand SLF, a thalidomide-derived cereblon ligand, and a linker. dFKBP-1 enables selective degradation of FKBP12 via the CRBN-mediated ubiquitin-proteasome pathway.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 1799711-22-0 |
| Applications | PROTAC FKBP12 Degrader |
| Formula | C53H64N6O14 |
| Molecular Weight | 1009.11 |
| SMILES | O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCC(NCCCCNC(COC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=O)=O)=O)=C2)CCC6=CC=C(OC)C(OC)=C6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.