dFKBP-1

Name: dFKBP-1
Brand: Adooq Bioscience
SKU: A23955
Rating: 5 (288 reviews)

Catalog No.: A23955

PROTAC FKBP12 Degrader

dFKBP-1 is a potent PROTAC-based degrader targeting FKBP12. It is composed of the FKBP12-binding ligand SLF, a thalidomide-derived cereblon ligand, and a linker. dFKBP-1 enables selective degradation of FKBP12 via the CRBN-mediated ubiquitin-proteasome pathway.

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dFKBP-1 1799711-22-0 PROTAC FKBP12 Degrader

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Grouped product items
Size	Price	Stock
1mg	$495.00	In stock
5mg	$1,080.00	In stock
10mg	$1,680.00	In stock
50mg	$4,860.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	dFKBP-1 is a potent PROTAC-based degrader targeting FKBP12. It is composed of the FKBP12-binding ligand SLF, a thalidomide-derived cereblon ligand, and a linker. dFKBP-1 enables selective degradation of FKBP12 via the CRBN-mediated ubiquitin-proteasome pathway.

Product Information

Catalog Num	A23955
Formula	C53H64N6O14
Molecular Weight	1009.11
CAS Number	1799711-22-0
SMILES	O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCC(NCCCCNC(COC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=O)=O)=O)=C2)CCC6=CC=C(OC)C(OC)=C6
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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