Fig. 1 · Structure
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DFP00173
AQP3 Inhibitor
DFP00173 is a selective inhibitor of aquaporin-3 (AQP3), demonstrating potent activity with an IC50 value of approximately 0.1-0.4 μM against both mouse and human AQP3. This compound exhibits a high degree of selectivity for AQP3, sparing the closely related isoforms AQP7 and AQP9. DFP00173 is valuable for investigating the physiological roles of AQP3 in various biological processes and contributes to research on water transport and osmoregulation in both pathological and physiological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 672286-03-2 |
| Applications | AQP3 Inhibitor |
| Formula | C11H7Cl2N3O3S |
| Molecular Weight | 332.16 |
| SMILES | O=C(NC1=CSC([N+]([O-])=O)=C1)NC2=C(Cl)C=CC=C2Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.