Fig. 1 · Structure
Documents & Downloads
DG013A
ERAP Inhibitor
DG013A is a phosphinic acid tripeptide mimetic that acts as an inhibitor of endothelial aminopeptidase ERAP1 and ERAP2, demonstrating IC50 values of 33 nM and 11 nM, respectively. This compound is valuable for studying pathways involved in autoimmune diseases and cancer, providing insights into the modulation of antigen processing and presentation. Researchers can utilize DG013A to explore therapeutic strategies targeting the ERAP enzymes in various disease contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2007955-07-7 |
| Applications | ERAP Inhibitor |
| Formula | C27H37N4O4P |
| Molecular Weight | 512.58 |
| SMILES | O=P([C@@H](N)CCC1=CC=CC=C1)(O)C[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC2=CNC3=CC=CC=C23)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.