Fig. 1 · Structure
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DG70
MenG Inhibitor
DG70 is a selective MenG inhibitor that disrupts respiration in Mycobacterium tuberculosis. It targetably inhibits the enzyme activity of demethylmenaquinone methyltransferase with an IC50 value of 2.6 ± 0.6 μM. This compound is particularly useful for research focused on tuberculosis (TB) and the mechanisms of mycobacterial respiration, offering insights into potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 930470-97-6 |
| Applications | MenG Inhibitor |
| Formula | C21H17ClFNO3 |
| Molecular Weight | 385.82 |
| Synonyms | GSK1733953A |
| SMILES | O=C(NC1=CC(C2=CC=C(OC)C=C2)=C(OC)C=C1)C3=CC=C(F)C=C3Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.