Fig. 1 · Structure
Documents & Downloads
DGK-IN-1
DGKα/ζ Inhibitor
DGK-IN-1 is an inhibitor of diacylglycerol kinase (DGK) isoforms DGKa and DGKz, with IC50 values of 0.65 µM and 0.25 µM, respectively. This compound serves as a potent T cell activator, making it valuable for studies related to cancer immunology and viral infections. By modulating T cell activity, DGK-IN-1 can aid in understanding immune responses and therapeutic strategies in various disease contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2407892-34-4 |
| Applications | DGKα/ζ Inhibitor |
| Formula | C29H27Cl2N5O |
| Molecular Weight | 532.46 |
| SMILES | N#CC1=NC2=C(N(C)C(C=C2N3[C@@H](C)CN(C(C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)[C@H](C)C3)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.