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DGKα-IN-3

DGKα Inhibitor

DGKα-IN-3 is a potent inhibitor of diacylglycerol kinase alpha (DGKα), exhibiting an IC50 of 283 nM. This compound has been shown to significantly enhance the anti-tumor activity of anti-PD-1 therapies by promoting T cell proliferation and function. DGKα-IN-3 is a valuable tool for cancer and immunology research, providing insights into T cell modulation and potential therapeutic applications in tumor immunotherapy.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2648418-86-2
Applications	DGKα Inhibitor
Formula	C₂₆H₂₇F₃N₄O₃
Molecular Weight	500.51
SMILES	O=C(C1=C(N2CCC3(CC2)CN(CC3)C4=CC=C(C=C4)OC(F)(F)F)C5=C(C=CC=C5)N(C)C1=O)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.