Fig. 1 · Structure
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DHC-156
Brachyury Downmodulator
DHC-156 is a selective downmodulator of Brachyury, a critical transcription factor involved in chordoma tumorigenesis. This compound effectively reduces Brachyury expression, making it a valuable tool for studying the molecular mechanisms underlying chordoma and exploring potential therapeutic strategies. Its application in chordoma research can aid in the identification of novel treatment modalities targeting Brachyury-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3115269-32-1 |
| Applications | Brachyury Downmodulator |
| Formula | C24H24F4N4O3 |
| Molecular Weight | 492.47 |
| SMILES | COC1=C(C=C2C(C=CN=C2NC3=CC(OCC(F)(F)F)=C(C=C3)F)=C1)NC(/C=C/CN(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.