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DHPG

Catalog No.: A61742
mGluR1/5 Agonist
DHPG is a potent agonist for metabotropic glutamate receptors mGluR1 and mGluR5, with an EC50 of 60 nM for mGluR1. Its activation triggers the phospholipase C (PLC) signaling pathway, subsequently activating protein kinase C (PKC). DHPG is widely utilized in research to explore synaptic transmission, neuroplasticity, and the therapeutic potential of targeting mGluR signaling in neurological disorders.
DHPG 146255-66-5 mGluR1/5 Agonist
Grouped product items
Size Price Stock Qty
5mg
$35.00
In stock
10mg
$55.00
In stock
25mg
$105.00
In stock
50mg
$190.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDHPG is a potent agonist for metabotropic glutamate receptors mGluR1 and mGluR5, with an EC50 of 60 nM for mGluR1. Its activation triggers the phospholipase C (PLC) signaling pathway, subsequently activating protein kinase C (PKC). DHPG is widely utilized in research to explore synaptic transmission, neuroplasticity, and the therapeutic potential of targeting mGluR signaling in neurological disorders.
Product Information
Catalog NumA61742
FormulaC8H9NO4
Molecular Weight183.16
CAS Number146255-66-5
SMILESO=C(O)C(N)C1=CC(O)=CC(O)=C1
Synonyms(RS)-3,5-DHPG
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GPCR/G Protein > Metabotropic glutamate receptors (mGluR)