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DHX9-IN-21

DHX9 Inhibitor

DHX9-IN-21 is a selective inhibitor of the helicase DHX9, exhibiting an IC50 of 2 nM and a cellular EC50 of 19.1 nM. This compound demonstrates significant antiproliferative activity against LS411N cells, a model of microsatellite unstable colorectal cancer, with an IC50 of 79.2 nM. DHX9-IN-21 is a valuable tool for studying the role of DHX9 in cancer biology and its potential as a therapeutic target in colorectal cancer research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2973401-72-6
Applications	DHX9 Inhibitor
Formula	C₂₀H₂₀ClN₅O₄S₂
Molecular Weight	493.99
SMILES	O=C(C1=CC(C2=NC=C(C=N2)OC3CNC3)=C(C)S1)NC4=CC(Cl)=CC(NS(=O)(C)=O)=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.