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di-Ellipticine-RIBOTAC TFA

r(G4C2)exp RIBOTAC Degrader

di-Ellipticine-RIBOTAC TFA is a RNase recruiting chimera (RIBOTAC) degrader targeting the expanded G4C2 RNA repeat (r(G4C2)exp). It selectively binds to the three-dimensional structure of r(G4C2)exp, recruiting endogenous ribonuclease to induce cleavage and degradation of this RNA. This compound effectively reduces the levels of the toxic dipeptide repeat proteins derived from the C9orf72 allele, thereby alleviating pathological phenotypes associated with amyotrophic lateral sclerosis and frontotemporal dementia in cellular and murine models. di-Ellipticine-RIBOTAC TFA is valuable for research into ALS and FTD.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2767983-77-5
Applications	r(G4C2)exp RIBOTAC Degrader
Formula	C₈₀H₈₈F₃N₇O₁₈S
Molecular Weight	1524.65
SMILES	CCOC(C1=C(S/C(C1=O)=C\C2=CC=C(C(O)=C2)OCCOCCOCCOCCNC(CCC(N(CCOCCOCCOC3=CC4=C(NC5=C4C(C)=C6C=NC=CC6=C5C)C=C3)CCOCCOCCOC7=CC=C8NC9=C(C(C)=C%10C=NC=CC%10=C9C)C8=C7)=O)=O)NC%11=CC=CC=C%11)=O.OC(C(F)(F)F)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

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Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.