Fig. 1 · Structure
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Dibenzo(a,i)pyrene
TCDD (Ah) Receptor Carcinogenic Ligand
Dibenzo(a,i)pyrene is a polycyclic aromatic hydrocarbon that serves as a carcinogenic ligand for the TCDD (Ah) receptor. It has been shown to induce DNA adduct formation while upregulating p53 and p21WAF1 protein levels in diploid lung fibroblasts. Additionally, Dibenzo(a,i)pyrene alters cell cycle dynamics, increasing the S phase population and leading to G0/G1 and G2/M phase decreases, resulting in S phase delay or arrest. This compound is relevant for applications in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 189-55-9 |
| Applications | TCDD (Ah) Receptor Carcinogenic Ligand |
| Formula | C24H14 |
| Molecular Weight | 302.37 |
| SMILES | C12=CC3=CC=C4C(C5=C6C(C=CC=C6)=C4)=C3C(C=C5)=C1C=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.