Fig. 1 · Structure
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Dibenzothiophene
Cat. No.
A16502
CAS
132-65-0
CYP1A Inhibitor
Dibenzothiophene is a noncompetitive inhibitor of cytochrome P450 1A (CYP1A), effectively inhibiting CYP1A-mediated ethoxyresorufin O-deethylation (EROD) activity with a Km value of 0.592 μM. This compound interacts with the aryl hydrocarbon receptor (AHR) pathway and has been shown to enhance the embryotoxicity of β-naphthoflavone. Its acute toxicity in animal models underscores its relevance in research. Dibenzothiophene is primarily utilized in studies investigating the mechanisms of developmental toxicity in various organisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 132-65-0 |
| Applications | CYP1A Inhibitor |
| Formula | C12H8S |
| Molecular Weight | 184.26 |
| Synonyms | DBT; Diphenylene sulfide |
| SMILES | C12=CC=CC=C1C3=CC=CC=C3S2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.