Fig. 1 · Structure
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Dichlorobenzamil
Na/Ca Exchange Inhibitor
Dichlorobenzamil is a potent inhibitor of the Na/Ca exchanger. It significantly reduces 45Ca uptake via reverse Na/Ca exchange in pancreatic islet cells, with an IC50 value of 18 µM. Additionally, Dichlorobenzamil has the capability to block K+ channels as well as voltage-sensitive Ca2+ channels, making it a valuable tool for research on calcium signaling and ion channel dynamics in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1166-01-4 |
| Applications | Na/Ca Exchange Inhibitor |
| Formula | C13H12Cl3N7O |
| Molecular Weight | 388.64 |
| Synonyms | 3',4'-Dichlorobenzamil; L-594881 |
| SMILES | O=C(C1=NC(Cl)=C(N)N=C1N)NC(NCC2=CC=C(C(Cl)=C2)Cl)=N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.