Fig. 1 · Structure
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Dichloromethotrexate
Antitumor Agent
Dichloromethotrexate is an orally active antitumor agent with a potent mechanism of action that inhibits dihydrofolate reductase. It exhibits significant antitumor effects against L1210 leukemia and C3H lymphosarcoma in murine models. This compound is primarily utilized in cancer research to explore therapeutic approaches and to study the mechanisms of tumor inhibition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 528-74-5 |
| Applications | Antitumor Agent |
| Formula | C20H20Cl2N8O5 |
| Molecular Weight | 523.33 |
| Synonyms | NSC-29630; 3',5'-Dichloromethotrexate |
| SMILES | NC1=NC(N)=NC2=NC=C(CN(C3=C(C=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3Cl)Cl)C)N=C12 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.