Diclofenac-d4

Catalog No.: A30733
Stable Isotope
Diclofenac-d4 is a deuterated form of Diclofenac, a potent nonselective cyclooxygenase (COX) inhibitor. It exhibits IC50 values of 4 nM for COX-1 and 1.3 nM for COX-2 in CHO cells, demonstrating its high efficacy in reducing inflammation. Additionally, Diclofenac has been shown to induce apoptosis in neural stem cells (NSCs) through the activation of the caspase cascade, making it valuable for research in both anti-inflammatory treatments and neurobiology studies.
Grouped product items
Size Price Stock Qty
1mg
$300.00
In stock
5mg
$835.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDiclofenac-d4 is a deuterated form of Diclofenac, a potent nonselective cyclooxygenase (COX) inhibitor. It exhibits IC50 values of 4 nM for COX-1 and 1.3 nM for COX-2 in CHO cells, demonstrating its high efficacy in reducing inflammation. Additionally, Diclofenac has been shown to induce apoptosis in neural stem cells (NSCs) through the activation of the caspase cascade, making it valuable for research in both anti-inflammatory treatments and neurobiology studies.
Product Information
Catalog NumA30733
FormulaC14H7D4Cl2NO2
Molecular Weight300.17
CAS Number153466-65-0
SMILESOC(CC(C([2H])=C([2H])C([2H])=C1[2H])=C1NC2=C(C=CC=C2Cl)Cl)=O
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