Fig. 1 · Structure
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Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Ferrochelatase Inhibitor
Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate acts as a ferrochelatase inhibitor and is identified for its role as a porphyrin inducer. This compound can induce small bile duct obstruction in murine models, leading to cholestasis characterized by impaired bile excretion. Prolonged exposure may result in damage to bile duct epithelial cells, inflammatory responses, and liver fibrosis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate serves as a valuable tool for modeling the pathological features associated with cholestatic liver diseases, including sclerosing cholangitis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 632-93-9 |
| Applications | Ferrochelatase Inhibitor |
| Formula | C14H21NO4 |
| Molecular Weight | 267.32 |
| SMILES | CC1C(C(OCC)=O)=C(NC(C)=C1C(OCC)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.