Fig. 1 · Structure
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Diethyl maleate
GSH Depletor
Diethyl maleate (DEM) is a potent glutathione (GSH) depletor that irreversibly binds to GSH via glutathione S-transferase, exhibiting an in vitro IC50 value of 0.1-0.5 mM. This compound effectively reduces GSH levels in liver, lung, and brain tissues, thereby enhancing oxidative stress and potentially increasing hyperbaric oxygen toxicity. Diethyl maleate is valuable in research related to redox homeostasis and GSH protective mechanisms, particularly in the context of oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 141-05-9 |
| Applications | GSH Depletor |
| Formula | C8H12O4 |
| Molecular Weight | 172.18 |
| Synonyms | Maleic acid diethyl ester |
| SMILES | O=C(OCC)/C=C\C(OCC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.