Fig. 1 · Structure
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Dihydrocoumarin
Sir2p Inhibitor
Dihydrocoumarin is a selective inhibitor of the Sir2p protein in yeast, playing a significant role in regulating cellular processes related to aging and metabolism. It also demonstrates inhibitory activity against human SIRT1 and SIRT2, with IC50 values of 208 μM and 295 μM, respectively. This compound is valuable for research applications in studies focused on aging, metabolic regulation, and the roles of sirtuins in cellular function.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 119-84-6 |
| Applications | Sir2p Inhibitor |
| Formula | C9H8O2 |
| Molecular Weight | 148.16 |
| Synonyms | Hydrocoumarin; Chroman-2-one |
| SMILES | O=C1CCC2=CC=CC=C2O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.