Fig. 1 · Structure
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Dihydrocurcumin
FASN Inhibitor
Dihydrocurcumin, a key metabolite of curcumin, acts as a fatty acid synthase (FASN) inhibitor. It is known to decrease lipid accumulation and oxidative stress by modulating the expression of key regulatory proteins such as SREBP-1C, PNPLA3, and PPARα. Additionally, Dihydrocurcumin enhances the protein levels of pAKT and PI3K while diminishing cellular nitric oxide (NO) and reactive oxygen species (ROS) through involvement in Nrf2 signaling pathways. This compound is valuable for investigating lipid metabolism and oxidative stress in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 76474-56-1 |
| Applications | FASN Inhibitor |
| Formula | C21H22O6 |
| Molecular Weight | 370.40 |
| SMILES | O=C(/C=C(O)/C=C/C1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.