Fig. 1 · Structure
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Dihydrocytochalasin B
Arp2/3 Complex
Dihydrocytochalasin B targets the Arp2/3 complex and acts as a potent cytokinesis inhibitor. It disrupts the actin cytoskeleton, leading to altered cell morphology similar to cytochalasin B, while selectively not affecting glucose transport. Dihydrocytochalasin B reversibly inhibits the initiation of DNA synthesis in response to growth factors, and additionally impacts calcium transport, resulting in elevated intracellular Ca2+ levels. This compound is valuable for research in cell division, cell motility, and intracellular signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 39156-67-7 |
| Applications | Arp2/3 Complex |
| Formula | C29H39NO5 |
| Molecular Weight | 481.62 |
| SMILES | O=C1[C@]2(O3)[C@]([C@@H](C([C@@H](O)[C@]2([H])/C=C/C[C@@H](CCC[C@@H](O)CCC3=O)C)=C)C)([H])[C@H](CC4=CC=CC=C4)N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.