Dihydroergotamine Mesylate

Catalog No.: A17764

Serotonin receptors agonist

Dihydroergotamine Mesylate

Dihydroergotamine Mesylate Chemical Structure

CAS NO. 6190-39-2

Dihydroergotamine Mesylate, also known as DHE or Migranal, is an ergot alkaloid used to treat migraines. It has similar actions to the triptans, acting as an agonist to the serotonin receptors and causing vasoconstriction of the intracranial blood vessels, but also interacts centrally with dopamine and adrenergic receptors.

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50 mg
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100 mg
$100.00
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Warning WARNING: Attention California Residents: This product can expose you to chemicals including Dihydroergotamine Mesylate , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Dihydroergotamine Mesylate, also known as DHE or Migranal, is an ergot alkaloid used to treat migraines. It has similar actions to the triptans, acting as an agonist to the serotonin receptors and causing vasoconstriction of the intracranial blood vessels, but also interacts centrally with dopamine and adrenergic receptors.
In vitro DMSO 99 mg/mL (145.63 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.71 mL 73.55 mL 147.11 mL
0.5 mM 2.94 mL 14.71 mL 29.42 mL
1 mM 1.47 mL 7.36 mL 14.71 mL
5 mM 0.29 mL 1.47 mL 2.94 mL

*The above data is based on the productmolecular weight 679.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17764
Actions Agonist
CAS No. 6190-39-2
Formula C34H41N5O8S
M. Wt 679.78
Purity >98%
Synonyms Dihydroergotamine Mesylate; DHE; Migranal;
SMILES O=C([[email protected]@H](CN(C)[[email protected]]1([H])C2)C[[email protected]]1([H])C3=C4C2=CNC4=CC=C3)N[[email protected]](C(N5[[email protected]]6CC7=CC=CC=C7)=O)(C)O[[email protected]@]5(O)[[email protected]]8([H])CCCN8C6=O.OS(=O)(C)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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