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Dihydroergotamine

Antimigraine Agent

Dihydroergotamine is a semisynthetic hydrogenated ergot alkaloid that acts primarily as an ant мигraine agent by stimulating alpha-adrenergic and 5-HT2A receptors, leading to vasoconstriction. This compound effectively penetrates the blood-brain barrier (BBB), making it valuable for investigating migraine pathophysiology and treatment mechanisms. Dihydroergotamine is widely used in research settings to explore migraine relief and associated vascular activities.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	511-12-6
Applications	Antimigraine Agent
Formula	C₃₃H₃₇N₅O₅
Molecular Weight	583.68
Synonyms	DFN-19
SMILES	O[C@@]([C@@](CCC1)([H])N1C2=O)(O[C@](NC([C@@H](CN(C)[C@]3([H])C4)C[C@]3([H])C5=C6C4=CNC6=CC=C5)=O)(C)C7=O)N7[C@H]2CC8=CC=CC=C8

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.