Fig. 1 · Structure
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Dihydromunduletone
Adhesion GPCR Antagonist
Dihydromunduletone (DHM) is a potent antagonist of adhesion G protein-coupled receptors (aGPCRs), specifically targeting GPR56 and GPR114 (ADGRG5) with an IC50 of 20.9 μM for GPR56. This compound has been shown to selectively inhibit aGPCR activity without affecting GPR110 or class A GPCRs. Dihydromunduletone is valuable for research applications aimed at elucidating the roles of aGPCRs in cellular signaling and adhesion processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 674786-20-0 |
| Applications | Adhesion GPCR Antagonist |
| Formula | C25H28O6 |
| Molecular Weight | 424.49 |
| SMILES | CC1(C)C=CC2=C(OC)C(CC(C3=C(O)C=C4C(CC(O)C(C)(C)O4)=C3)=O)=CC=C2O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.