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Dihydrouracil-Ph-2-Me-piperidine

Ligands for E3 Ligase

Dihydrouracil-Ph-2-Me-piperidine serves as a ligand for E3 ligase, facilitating targeted protein degradation through the PROTAC technology. It is instrumental in synthesizing the PROTAC HPK1 Degrader-6, which can be employed in studies aimed at modulating cellular pathways by specifically degrading target proteins. This compound is valuable for researchers investigating the therapeutic potential of PROTACs and E3 ligase-mediated protein degradation in various biological contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3027839-56-8
Applications	Ligands for E3 Ligase
Formula	C₁₆H₂₁N₃O₂
Molecular Weight	287.36
SMILES	O=C(N1)N(C2=CC=C(C3CCNCC3)C=C2C)CCC1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.