Dihydrouracil-Ph-2-Me-piperidine

Catalog No.: A80674
Ligands for E3 Ligase
Dihydrouracil-Ph-2-Me-piperidine serves as a ligand for E3 ligase, facilitating targeted protein degradation through the PROTAC technology. It is instrumental in synthesizing the PROTAC HPK1 Degrader-6, which can be employed in studies aimed at modulating cellular pathways by specifically degrading target proteins. This compound is valuable for researchers investigating the therapeutic potential of PROTACs and E3 ligase-mediated protein degradation in various biological contexts.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDihydrouracil-Ph-2-Me-piperidine serves as a ligand for E3 ligase, facilitating targeted protein degradation through the PROTAC technology. It is instrumental in synthesizing the PROTAC HPK1 Degrader-6, which can be employed in studies aimed at modulating cellular pathways by specifically degrading target proteins. This compound is valuable for researchers investigating the therapeutic potential of PROTACs and E3 ligase-mediated protein degradation in various biological contexts.
Product Information
Catalog NumA80674
FormulaC16H21N3O2
Molecular Weight287.36
CAS Number3027839-56-8
SMILESO=C(N1)N(C2=CC=C(C3CCNCC3)C=C2C)CCC1=O
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