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Dimethoxycurcumin

Name: Dimethoxycurcumin
Brand: Adooq Bioscience
SKU: A15804
Availability: InStock

Cat. No. A15804 CAS 160096-59-3

Analog of curcumin

Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS.

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Biological Activity

Cellular Effect

Cell Line	Activity	Value	Description	Reference
HEK293	CC50	> 20 μM	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability at 20 uM measured after 48 hrs by resazurin reagent based multilabel reader analysis	[PMID: 36608774]
HEK293	EC50	200 μM	Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay	[PMID: 20004045]
MCF7	IC50	1.07 μM	Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay	[PMID: 19019687]
SK-BR-3	IC50	0.955 μM	Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay	[PMID: 19019687]

Specifications

Manufacturer	Adooq Bioscience
CAS Number	160096-59-3
Applications	Analog of curcumin
Formula	C₂₃H₂₄O₆
Molecular Weight	396.4
SMILES	COC1=C(C=C(C=C1)C=CC(=CC(=O)C=CC2=CC(=C(C=C2)OC)OC)O)OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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Dimethoxycurcumin

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DMSO Solution