Fig. 1 · Structure
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Dimethyl succinate
Succinate Analogue
Dimethyl succinate is a cell-permeable analogue of succinate that primarily disrupts the tricarboxylic acid (TCA) cycle by increasing intracellular succinate levels. This compound inhibits protein synthesis and impairs myogenic differentiation while also inducing apoptosis. Additionally, dimethyl succinate decreases maximal cellular respiration and reserve capacity, with potential applications in rescuing synapse loss in Alzheimer's disease. It serves as a valuable reagent for research into metabolic and neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 106-65-0 |
| Applications | Succinate Analogue |
| Formula | C6H10O4 |
| Molecular Weight | 146.14 |
| SMILES | O=C(OC)CCC(OC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.