Fig. 1 · Structure
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Dimethylsildenafil
Sildenafil Derivative
Dimethylsildenafil is a derivative of Sildenafil, functioning as a potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 5.22 nM. This compound exhibits significant biological activity by promoting vasodilation through increased intracellular levels of cyclic GMP. It is utilized in research applications focused on cardiovascular diseases and erectile dysfunction, providing insights into the modulation of nitric oxide signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1416130-63-6 |
| Applications | Sildenafil Derivative |
| Formula | C23H32N6O4S |
| Molecular Weight | 488.60 |
| SMILES | O=C1NC(C2=C(OCC)C=CC(S(=O)(N3CC(C)NC(C)C3)=O)=C2)=NC4=C1N(C)N=C4CCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.